Interpregnancy maternal weight change is not associated with offspring weight and obesity at age 2 years
Authors' conclusion
Sibling obesity and being born LGA were most strongly independently associated with overweight/obesity at 2 years. This supports the need for family interventions and to address risk factors for development of LGA infants. There was no independent association with interpregnancy weight gain, contrary to what was hypothesised.
Study context
- Population
- Women with first and second live births 2009–2018, linked perinatal and child datasets, Flanders, Belgium
- Participants
- 33,172 women
- Exposure
- Interpregnancy maternal BMI change
- Stable BMIn = 17,478reference
- Moderaten = 8,024
- Substantialn = 2,821
- Outcome
- Overweight/obesity in the second child
- Follow-up
- 2 years
Methodological detailspopulation-based, routinely collected linked data, logistic regression
- Population-based
- Routinely collected linked data
- Logistic regression
Main finding
As reported in the abstract
Overweight/obesity in second child
- No statistical evidence that maternal interpregnancy BMI change is independently associated with overweight/obesity in the second child (multivariate analysis)
Observational data: associations, not effects.
Further findings
Weight status of second offspring · 2 years
- Healthy weight
- 91.6% (n = 30383)
- Underweight
- 0.6% (n = 210)
- Overweight
- 7.0% (n = 2312)
- Obesity
- 0.8% (n = 267)
Independent factors for overweight/obesity in second child at 2 years
- Sibling in obesity category at 2 years, OR
- 7.2 (5.49-9.45) (95% CI)
- Born Large for Gestational Age (LGA), OR
- 2.13 (1.92-2.37)
- Maternal African origin, OR
- 1.90 (1.59-2.26)
- Maternal obesity at start of first pregnancy, OR
- 1.33 (1.16-1.53)
- Excessive gestational weight gain in second pregnancy, OR
- 1.15 (1.04-1.28)
- Born after <1-year interpregnancy interval, OR
- 1.17 (1.05-1.30)
- Not exclusively breastfed at 12 weeks, OR
- 1.29 (1.10-1.52)
- Multivariate analysis
Original publication
Interpregnancy maternal weight change is not associated with offspring weight and obesity at age 2 years. Int J Obes (Lond). Published 13 June 2024. doi:10.
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