A Plasma Metabolite Score Related to Psychological Distress and Diabetes Risk: A Nested Case-control Study in US Women
Authors' conclusion
MDS was significantly associated with diabetes risk in women. These results suggest that differences in multiple lipid and amino acid metabolites may underlie the observed association between psychological distress and diabetes risk.
Study context
- Population
- Women in the Nurses' Health Study: 728 with incident diabetes (mean age 55.2 years) and 728 matched controls; blood collected 1989–1990, diabetes diagnosed 1992–2008728 cases · 728 matched controls
- Comparison
- Quintiles of plasma metabolite-based distress score
- Outcome
- Incident diabetes risk according to weighted plasma MDS (19 metabolites)
Methodological detailsmatched controls, conditional logistic regression
- Matched controls
- Conditional logistic regression
Main finding
As reported in the abstract
Diabetes risk by MDS quintile, adjusted for sociodemographic factors, family history and health behaviors
Each group vs Q1Odds ratio (95% CI)
Q2
1.16(0.77–1.73)
Q3
1.30(0.88–1.91)
Q4
1.99(1.36–2.92)
Q5
2.47(1.66–3.67)
- Per SD increase in MDS: higher diabetes risk
- 36% (95% CI: 1.21, 1.54; P-trend <.0001)
Observational data: associations, not effects.
Further findings
Per SD increase in MDS, additionally adjusted for BMI
- OR (95% CI: 1.02, 1.35; P-trend = .02); moderately attenuated
- 1.17
Proportion of association between self-reported psychological distress and diabetes risk explained by MDS
- Explained by MDS (P = .04)
- 17.6%
Original publication
A Plasma Metabolite Score Related to Psychological Distress and Diabetes Risk: A Nested Case-control Study in US Women. J Clin Endocrinol Metab. Published 13 December 2023. doi:10.
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