A novel approach to hypophysitis: outcomes using non-glucocorticoid immunosuppressive therapy
Authors' conclusion
Subjects with hypophysitis receiving NGIT had stable or improved brain/pituitary magnetic resonance imaging findings with a significant decrease in pituitary stalk thickness. NGITs did not improve anterior pituitary function. Our findings suggest that NGIT may be considered as an alternative therapy for patients with hypophysitis who require immunosuppression.
Study context
- Population
- Subjects with hypophysitis treated with nonglucocorticoid immunosuppressive therapy (NGIT)
- Participants
- 12 subjects
- Exposure
- Pituitary function and outcomes before vs after NGIT
- Primary hypophysitis (PH)n = 5
- Secondary hypophysitis (SH)n = 7
- Outcome
- Pituitary stalk thickness after NGIT
- Follow-up
- Mean duration 16.5 ± 4.8 months
Main finding
As reported in the abstract
- Significant decrease in mean pituitary stalk thickness after NGIT
- P = .0051
Observational data: associations, not effects.
Further findings
Polyuria/polydipsia · presentation
Fatigue at presentation
- Most common symptom at presentation: fatigue
- 75%
Safety
Discontinuation of mycophenolate mofetil due to adverse effects
- Adverse effects prompted discontinuation of mycophenolate mofetil
- 2 out of 7 subjects
Original publication
A novel approach to hypophysitis: outcomes using non-glucocorticoid immunosuppressive therapy. Eur J Endocrinol. Published 21 August 2023. doi:10.
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