Nonalcoholic Fatty Liver Disease, Liver Fibrosis, and Utility of Noninvasive Scores in Patients With Acromegaly
Authors' conclusion
Active acromegaly may protect from NAFLD because of high GH. In patients with acromegaly, NAFLD risk cannot be explained with classical risk factors; hence, additional risk factors must be identified. TyG is the best score to evaluate NAFLD risk. Lower ANGPTL-8 in patients with acromegaly and NAFLD implies this hormone may be raised because of insulin resistance rather than being a cause for NAFLD.
Study context
- Population
- Patients with acromegaly (active or controlled) and healthy controls; hepatic steatosis by MRI-PDFF, liver stiffness by MR elastography, ANGPTL-8 by ELISA32 with acromegaly
- Participants
- 15 / 17 / 19
- Exposure
- Active vs controlled acromegaly vs healthy controls
- AAn = 15
- CAn = 17
- Healthy controlsn = 19reference
- Outcome
- Liver MRI-PDFF and NAFLD prevalence
Main finding
As reported in the abstract
- AA vs CA: P = 0.026
- AA vs CA: P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| GH, IGF-1 and ANGPTL-8 in acromegaly with vs without NAFLDAcromegaly with NAFLD vs Acromegaly without NAFLD · lower with NAFLD | P = 0.025 |
| GH, IGF-1 and ANGPTL-8 in acromegaly with vs without NAFLDAcromegaly with NAFLD vs Acromegaly without NAFLD · lower with NAFLD | P = 0.011 |
| GH, IGF-1 and ANGPTL-8 in acromegaly with vs without NAFLDAcromegaly with NAFLD vs Acromegaly without NAFLD · lower with NAFLD | P = 0.036 |
MR elastography liver stiffness
- Median MR elastography liver stiffness similar across groups
Noninvasive scores vs liver MRI-PDFF
- Visceral adiposity index, fatty liver index, hepatic steatosis index and TyG all correlated positively with liver MRI-PDFF in controls
- Only TyG significantly correlated with liver fat in AA and CA
Traditional nonalcoholic fatty liver disease (NAFLD) risk factors vs liver MRI-PDFF in acromegaly
- No correlation of BMI, waist circumference, CRP, HOMA-IR or visceral adipose tissue with liver MRI-PDFF in AA and CA
Original publication
Nonalcoholic Fatty Liver Disease, Liver Fibrosis, and Utility of Noninvasive Scores in Patients With Acromegaly. J Clin Endocrinol Metab. Published 17 August 2023. doi:10.
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