A low serum alkaline phosphatase may signal hypophosphatasia in osteoporosis clinic patients
Authors' conclusion
Persistently low ALP in osteoporosis clinic attendees is easy to identify and signals the possibility of hypophosphatasia, a condition that may be mistaken for osteoporosis and incorrectly treated with antiresorptive therapy.
Study context
- Population
- Patients attending an osteoporosis clinic at a tertiary hospital (2012–2020), hospital-wide records and patients with atypical femoral fractures (AFF)
- Exposure
- Osteoporosis clinic vs Hospital-wide vs AFF
- Osteoporosis clinicn = 1,839
- AFFn = 22
- Outcome
- Prevalence of a low ALP (< 30 IU/L)
Methodological detailssingle tertiary hospital, 8 years (2012-2020)
- Single tertiary hospital
- 8 years (2012-2020)
Main finding
As reported in the abstract
Low ALP (< 30 IU/L), prevalence
| Group | Value | Low alkaline phosphatase (ALP) for ≥ 2 months | Persistently low ALP |
|---|---|---|---|
| Osteoporosis clinic | 9% | 50 (2.7%) | seven (0.4%) |
| Hospital-wide | 0.6% | ||
| AFF | 2/22 |
Value
Osteoporosis clinic9%
Hospital-wide0.6%
AFF2/22
Low alkaline phosphatase (ALP) for ≥ 2 months
Osteoporosis clinic50 (2.7%)
Hospital-wide— not stated in the abstract
AFF— not stated in the abstract
Persistently low ALP
Osteoporosis clinicseven (0.4%)
Hospital-wide— not stated in the abstract
AFF— not stated in the abstract
Observational data: associations, not effects.
Further findings
- Low ALP (< 30 IU/L), hospital-wide and AFF — AFF
- 2/22 events
- Hypophosphatasia (HPP) diagnosed — HPP patients with persistently low ALP
- 4
- HPP diagnosed: ≥ 1 low ALP 3%
- Low ALP (< 30 IU/L), hospital-wide and AFF: Hospital patients 0.6%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A low serum alkaline phosphatase may signal hypophosphatasia in osteoporosis clinic patients. Osteoporos Int. Published 24 November 2022. doi:10.
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