Asian ethnicity is associated with shorter antiresorptive exposure prior to atypical femur fracture (AFF): a Transcontinental Atypical Femoral Fracture Consortium (TrAFFiC) cohort study
Authors' conclusion
In conclusion, Asian individuals sustained AFFs following a shorter duration of anti-resorptive treatment compared with non-Asian AFF peers. In addition, Asian individuals were less likely to sustain additional minimal trauma fractures.
Study context
- Population
- Patients with atypical femur fractures in the TrAFFiC AFF registry; 77 (46%) with bilateral atypical femur fractures (AFFs), totalling 243 AFFs (138 complete, 105 incomplete)
- Participants
- 166 patients
- Exposure
- Asian vs non-Asian ethnicity among patients with AFF
- Asiann = 62
- Outcome
- "Earlier onset" AFF: AFF sustained following ≤ 5 years of anti-resorptive treatment
Methodological detailsregistry-based, Transcontinental Atypical Femoral Fracture Consortium (TrAFFiC)
- Registry-based
- Transcontinental Atypical Femoral Fracture Consortium (TrAFFiC)
Main finding
As reported in the abstract
"Earlier onset" AFF (after ≤ 5 years of anti-resorptive treatment)
Odds ratio (95% CI)P value
Asianvs Non-Asian
2.10(1.06–4.02)
P = 0.034Southeast AsianSoutheast Asian ethnicity, n=40 (24%)
3.25(1.55–6.8)
P = 0.002Observational data: associations, not effects.
Further findings
Height
P < 0.038
Weight
P < 0.001
History of minimal trauma fractures prior to AFF
P < 0.001
Teriparatide after incomplete AFF
- Teriparatide use following incomplete AFF (n=34) did not affect time to healing or pain resolution
Original publication
Asian ethnicity is associated with shorter antiresorptive exposure prior to atypical femur fracture (AFF): a Transcontinental Atypical Femoral Fracture Consortium (TrAFFiC) cohort study. J Bone Miner Res. Published 16 April 2026. doi:10.
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