Women’s reproductive risk and genetic predisposition in type 2 diabetes: A prospective cohort study
Authors' conclusion
Our novo developed RRS identified high reproductive risk is associated with elevated risk of women's T2D, which can be magnified by gene-reproductive interaction.
Study context
- Population
- Women with genetic data and reproductive factors, enrolled 2006–2010 in the UK Biobank; Reproductive risk score (RRS) based on 17 reproductive items, genetic risk score (GRS) on 149 genetic variants
- Participants
- 84,254 women
- Exposure
- Reproductive risk score categories; interaction with genetic risk score
- Outcome
- Incident T2D
- Follow-up
- Average 4.49 years
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
T2D risk
Each group vs low reproductive riskAdjusted hazard ratio (95 % CI)
High-mediate reproductive risk
1.38(1.20–1.58)
High reproductive risk
1.84(1.54–2.19)
- Significant increase in T2D risk across RRS categories
- P for trend < 0.001
- T2D cases
- 2300 (2.8 %)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95 % CI) | |
|---|---|---|
| Gene-reproductive interaction: T2D risk with high genetic predispositionLow reproductive riskvs High reproductive riskIn high genetic predisposition | 0.47 (0.30–0.76) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- Gene-reproductive interaction: T2D risk with high genetic predisposition — Absolute risk reduction (low vs high reproductive risk, high genetic predisposition)
- 2.98 %
Gene-reproductive interaction: T2D risk with high genetic predisposition
- Significant additive interaction between reproductive risk and genetic predisposition
Original publication
Women’s reproductive risk and genetic predisposition in type 2 diabetes: A prospective cohort study. Diabetes Res Clin Pract. Published 1 February 2024. doi:10.
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