Safety and Efficacy of Insulins in Critically Ill Patients Receiving Continuous Enteral Nutrition
Authors' conclusion
Administration of IA and LA insulin can be safe and effective for those receiving insulin doses for EN-related hyperglycemia.
Study context
- Population
- Critically ill patients on continuous enteral nutrition, with or without diabetes, single centre, 2019303 with known diabetes
- Participants
- 475 patients
- Exposure
- Intermediate-acting (IA) NPH 70/30 vs long-acting (LA) insulin vs rapid-acting insulin only
- Outcome
- Glucose in target range (70-180 mg/dL) and hyperglycemia, patients with T2D
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- IA and LA regimens associated with significantly higher proportion of patient-days in target range and fewer hyperglycemic days
Observational data: associations, not effects.
Safety
Hypoglycemia level 1 (<70 mg/dL) and level 2 (<54 mg/dL)
- Level 1 and level 2 hypoglycemia occurred rarely; no significant differences in level 2 hypoglycemia frequency across insulin regimens
Original publication
Safety and Efficacy of Insulins in Critically Ill Patients Receiving Continuous Enteral Nutrition. Endocr Pract. Published 1 February 2024. doi:10.
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