Weight change, variability, and trajectories and risk of hip fracture among older adults with dysglycemia: the cardiovascular health study
Authors' conclusion
Among older adults with dysglycemia at high risk for fracture, lower mean weight is associated with higher fracture risk, but variability and trajectory may also contribute.
Study context
- Population
- Older adults with dysglycemia (abnormal OGTT in 1989–1990), Cardiovascular Health Study; mean age 77.4 years775 men · 1080 women
- Exposure
- Weight change, variability and trajectories and hip fracture risk
- Outcome
- Subsequent hip fracture
- Follow-up
- Through 2015
Methodological detailsCox proportional hazards models, growth mixture modeling of BMI trajectories
- Cox proportional hazards models
- Growth mixture modeling of BMI trajectories
Main finding
As reported in the abstract
Hip fracture
Each 10 kg higher mean weight, overall: HR
0.81 (0.70-0.94) (CI)
Each 10 kg higher mean weight, women: HR
0.76 (0.64-0.91) (CI)
Higher weight variability, women: HR
1.18 (1.03-1.35) (CI)
"Progressive overweight" vs stable trajectory: HR
0.66 (0.44-0.99) (CI)
Observational data: associations, not effects.
Further findings
Hip BMD (cross-sectional)
- Each 10 kg higher mean weight associated with higher BMD
- P < 0.001
- Uncommon "accelerating obesity" trajectory associated with higher BMD
Original publication
Weight change, variability, and trajectories and risk of hip fracture among older adults with dysglycemia: the cardiovascular health study. J Bone Miner Res. Published 4 September 2024. doi:10.
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