Weekend warrior physical activity pattern, metabolomic profiles, and risk of osteoporosis and fracture
Authors' conclusion
The weekend warrior pattern was associated with lower risks of osteoporosis and fracture. We further identified distinct metabolomic signature characterizing this pattern, providing potential mechanistic insights into its protective effects.
Study context
- Population
- UK Biobank participants with accelerometer and metabolomic data
- Participants
- 14,069 participants
- Exposure
- Weekend warrior pattern vs inactive
- Outcome
- Osteoporosis and fracture risk
- Follow-up
- Median 7.8 years
Methodological detailsUK Biobank, accelerometer and metabolomic data, elastic net regression, Cox proportional hazards models, stratified by polygenic risk scores (PRS)
- UK Biobank
- Accelerometer and metabolomic data
- Elastic net regression
- Cox proportional hazards models
- Stratified by PRS
Main finding
As reported in the abstract
Weekend warrior vs InactiveHazard ratio (95% CI)
Osteoporosis
0.59(0.44–0.79)
Fracture
0.77(0.63–0.95)
- Osteoporosis cases
- 267
- Fracture events
- 554
Observational data: associations, not effects.
Further findings
Metabolomic signatures
- Metabolites characterizing weekend warrior pattern
- 51
- Metabolites representing regular physical activity
- 62
Weekend warrior-related metabolomic signature, per SD increase
- Osteoporosis, HR (95% CI 0.62-0.85); 27% lower risk
- 0.73
- Fracture, HR (95% CI 0.79-0.99); 12% lower risk
- 0.88
Effect modification by genetic susceptibility (PRS)
- Not significantly modified for osteoporosis
- P = 0.429
- Not significantly modified for fracture
- P = 0.221
Original publication
Weekend warrior physical activity pattern, metabolomic profiles, and risk of osteoporosis and fracture. J Bone Miner Res. Published 14 April 2026. doi:10.
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