Accelerometer-measured weekly and diurnal moderate-to-vigorous physical activity patterns and incident osteoporosis
Authors' conclusion
Accumulating MVPA predominantly within 1-2 days confers osteoprotective benefits comparable to evenly distributed weekly activity. Furthermore, the optimal time for osteoporosis risk reduction occurs during evening and mid-morning, followed by early-morning.
Study context
- Population
- UK Biobank participants with valid wrist-worn accelerometer data1,544 incident osteoporosis (OP)
- Participants
- 69,310 participants
- Exposure
- Active weekend warrior and active regular moderate-to-vigorous physical activity (MVPA) patterns vs inactive; diurnal MVPA timing patterns vs early-afternoon
- Outcome
- Incident osteoporosis (ICD-10 M80, M81, M82)
- Follow-up
- Median 7.7 years
Methodological detailsUK Biobank, wrist-worn accelerometer, multivariable-adjusted, K-means clustering of diurnal MVPA patterns
- UK Biobank
- Wrist-worn accelerometer
- Multivariable-adjusted
- K-means clustering of diurnal MVPA patterns
Main finding
As reported in the abstract
Incident osteoporosis, multivariable-adjusted
Each group vs inactiveHazard ratio (95% CI)
Active WW
0.78(0.69–0.89)
Active regular
0.77(0.67–0.87)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident osteoporosis by diurnal MVPA pattern (guideline-adherent individuals)Eveningvs Early-afternoon | 0.67 (0.52–0.87) | |
| Incident osteoporosis by diurnal MVPA pattern (guideline-adherent individuals)Mid-morningvs Early-afternoon | 0.69 (0.54–0.87) | |
| Incident osteoporosis by diurnal MVPA pattern (guideline-adherent individuals)Early-morningvs Early-afternoon | 0.77 (0.64–0.92) | |
| 0.512Hazard ratio (log scale) |
Original publication
Accelerometer-measured weekly and diurnal moderate-to-vigorous physical activity patterns and incident osteoporosis. Osteoporos Int. Published 3 November 2025. doi:10.
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