Visceral and subcutaneous adiposity and cardiovascular disease: Unravelling associations and prognostic value
Authors' conclusion
Incorporating VAT measurements alongside WC data improved the ability to identify individuals at high risk for CHD compared to using WC alone. Both VAT and WC proved to be more accurate indicators of CHD risk than ASAT. However, VAT alone did not fully account for the CHD risk associated with elevated WC levels. Neither VAT nor ASAT showed an association with the risk of stroke, HF and AF.
Study context
- Population
- General population, UK Biobank participants with available abdominal MRI data
- Participants
- 24,265 participants
- Comparison
- Visceral adipose tissue (VAT) and abdominal subcutaneous adipose tissue (ASAT) vs waist circumference (WC) as predictors of cardiovascular disease (CVD) events
- Primary endpoint
- Coronary heart disease (CHD)
- Follow-up
- Mean 12.9 ± 1.8 years
Methodological detailsabdominal MRI, Cox regression
- Abdominal MRI
- Cox regression
Primary result
As reported in the abstract
CHD
Each group vs concordant VAT and WC<medianHazard ratio (95% CI)
Discordant VAT>median, WC<median
1.43(1.15–1.78)
Discordant WC>median, VAT<median
1.46(1.18–1.81)
- HR for coronary heart disease (CHD) per 1 SD increase in VAT
- 1.15 (95% CI 1.09-1.22)
- HR for CHD per 1 SD increase in ASAT
- 1.10 (95% CI 1.04-1.18)
Secondary outcomes
CVD events (CHD, stroke, heart failure (HF), atrial fibrillation (AF)) · mean follow-up 12.9 ± 1.8 years
- Participants with CVD events
- 2641
- CHD
- 1296
- Stroke
- 165
- HF
- 286
- AF
- 894
Stroke, HF, AF
- No association between VAT or ASAT and risks of stroke, HF or AF after further adjustment for WC
Original publication
Visceral and subcutaneous adiposity and cardiovascular disease: Unravelling associations and prognostic value. Diabetes Obes Metab. Published 23 September 2024. doi:10.
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