Diabetes mellitus and adverse clinical events in patients with atrial fibrillation: A report from the GLORIA ‐ atrial fibrillation (AF) registry phase III
Authors' conclusion
DM was independently associated with higher risks of all-cause death, CV death, MI, major bleeding and MACE in AF individuals. Individuals receiving insulin alone were associated with higher risks of all-cause death, CV death, MI, major bleeding and MACE.
Study context
- Population
- Individuals with AF in the prospective GLORIA-AF registry; age 70.0 ± 10.2 years, 55% male, 20% Asian
- Participants
- 15,861 individuals
- Exposure
- Diabetes mellitus (DM) vs no DM; insulin alone vs oral hypoglycaemic agents in DM
- DMn = 3,666
- Outcome
- Adverse events, DM vs no DM (adjusted)
- Follow-up
- 3-year follow-up
Methodological detailsGLORIA-AF registry phase III, 3-year follow-up, adjusted analysis
- GLORIA-AF registry phase III
- 3-year follow-up
- Adjusted analysis
Main finding
As reported in the abstract
DM vs No DMHazard ratio (95% CI)
All-cause death
1.46(1.28–1.66)
CV death
1.53(1.27–1.86)
Major bleeding
1.23(1.01–1.48)
MI
1.50(1.17–1.94)
MACE
1.42(1.23–1.63)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Insulin alone vs oral hypoglycaemic agents in DM: all-cause death, CV death, major bleeding, MI and MACE (adjusted) · 3-year follow-upInsulin alonevs oral hypoglycaemic agentsAll-cause death | 2.16 (1.61–2.91) | |
| Insulin alone vs oral hypoglycaemic agents in DM: all-cause death, CV death, major bleeding, MI and MACE (adjusted) · 3-year follow-upInsulin alonevs oral hypoglycaemic agentsCV death | 2.24 (1.45–3.47) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | HR (95% CI) |
|---|---|
| Insulin alone vs oral hypoglycaemic agents in DM: all-cause death, CV death, major bleeding, MI and MACE (adjusted) · 3-year follow-upInsulin alone vs oral hypoglycaemic agents · major bleeding | 1.89 (1. 21-2.95) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Diabetes mellitus and adverse clinical events in patients with atrial fibrillation: A report from the GLORIA ‐ AF registry phase III. Diabetes Obes Metab. Published 20 September 2024. doi:10.
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