Vertebral Body Reshaping after Fractures: An Important Index of Recovery in Glucocorticoid-Treated Children
Authors' conclusion
After experiencing a VF, children with higher GC exposure, higher SDI, more severe fractures, or lumbar VF were at increased risk for persistent vertebral deformity.
Study context
- Population
- Glucocorticoid (GC)-treated children with leukemia, rheumatic disorders and nephrotic syndrome with vertebral fracture (VF) evaluated on lateral spine radiographs ≥1 year after VF detection; mean age 7.4 years
- Participants
- 79 children
- Outcome
- Spontaneous vertebral body reshaping after VF
Methodological details6-year study
- 6-year study
Main finding
As reported in the abstract
- Children with complete vertebral body reshaping
- 65 (82.3%)
- Median time from VF detection to complete reshaping (Cox proportional hazard modeling)
- 1.3 years
- VF that ultimately reshaped, of 237 VF
- 83.1%
- VF reshaping, thoracic vs lumbar region
- 87.2% vs 70.7% (P = .004)
- Every g/m² increase in GC exposure in first year after VF detection: decline in probability of reshaping
- 19%
- Each unit increase in spinal deformity index (SDI) at VF detection: probability of reshaping
- HR = 0.81; 95% CI = 0.71, 0.92; P = .001
- Each additional VF at VF detection: reshaping
- HR = 0.75; 95% CI = 0.62, 0.90; P = .002
- Each higher grade of VF severity: reshaping
- HR = 0.35; 95% CI = 0.21, 0.57; P < .001
Observational data: associations, not effects.
Original publication
Vertebral Body Reshaping after Fractures: An Important Index of Recovery in Glucocorticoid-Treated Children. J Clin Endocrinol Metab. Published 16 October 2023. doi:10.
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