Association between vertebral fractures and brain volume: insights from a community cohort study
Authors' conclusion
These findings suggest that VF is associated with significant reductions in brain regions critical for memory, emotional processing, and visuospatial memory, with more severe effects observed in males.
Study context
- Population
- Participants of the population-based Research on Osteoarthritis/Osteoporosis Against Disability study, fourth survey (2015–2016); mean age 64.9, range 18–97571 males · 1,180 females
- Participants
- 1,751 participants
- Exposure
- Vertebral fractures vs no vertebral fractures
- Vertebral fractures (VF)+n = 113
- VF-n = 1,638reference
- Outcome
- Gray matter volume (GMV) on MRI by voxel-based morphometry
Methodological detailspopulation-based community cohort (ROAD study, fourth survey 2015-2016), voxel-based morphometry, general linear model adjusted for age, sex, total brain volume and MMSE scores, two-way analysis of variance for sex × VF interaction
- Population-based community cohort (ROAD study, fourth survey 2015-2016)
- Voxel-based morphometry
- General linear model adjusted for age, sex, total brain volume and MMSE scores
- Two-way analysis of variance for sex × VF interaction
Main finding
As reported in the abstract
Gray matter volume
- Significant cluster with reduced gray matter volume (GMV) in VF+ vs VF-, including right hippocampus, right amygdala and right parahippocampal gyrus
- Adjusted for age, sex, total brain volume and MMSE scores
Observational data: associations, not effects.
Further findings
Sex differences in GMV reduction (significant cluster)
- Males in VF+ showed more pronounced GMV reductions in the significant cluster than females
Original publication
Association between vertebral fractures and brain volume: insights from a community cohort study. Osteoporos Int. Published 5 February 2025. doi:10.
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