Association between urinary catecholamines and glucocorticoids and bone mineral density and osteoporosis in Puerto Rican adults
Authors' conclusion
Higher urinary epinephrine and norepinephrine were associated with poorer bone outcomes in Puerto Rican adults, in a sex-specific manner, warranting future longitudinal studies to clarify associations.
Study context
- Population
- Boston Puerto Rican Health Study participants (aged 59.9 ± 7.6 yr); osteoporosis analyses in postmenopausal females and males
- Participants
- 958 participants
- Exposure
- Elevated vs non-elevated urinary stress markers
- Outcome
- BMD (DXA) and osteoporosis
Main finding
As reported in the abstract
Higher urinary epinephrine and BMD
- Higher urinary epinephrine associated with lower BMD at LS
- p = .012
- Higher urinary epinephrine associated with lower BMD at FN
- p = .005
- Higher urinary epinephrine associated with lower BMD at trochanter
- p < .001
- Higher urinary epinephrine associated with lower BMD at TH
- p < .001
- No associations for norepinephrine or cortisol
- p > .11
Observational data: associations, not effects.
Further findings
Osteoporosis in males: higher urinary epinephrine
- Higher urinary epinephrine associated with higher odds of osteoporosis among males: OR
- 4.01 (1.11, 14.5), p = .03 (95% CI)
- Multivariable logistic regression, adjusted for age, height, smoking, alcohol use, education, glucocorticoid use and diabetes
Interaction Dietary Approaches to Stop Hypertension (DASH) × norepinephrine, LS BMD, postmenopausal females
- An interaction between DASH and norepinephrine was noted for postmenopausal females at the LS
Norepinephrine or cortisol and bone outcomes
- No associations for norepinephrine or cortisol
- P > 0.11
- Higher urinary norepinephrine associated with lower LS BMD in postmenopausal females not taking estrogen, with lower adherence to DASH
- P = 0.03
Original publication
Association between urinary catecholamines and glucocorticoids and bone mineral density and osteoporosis in Puerto Rican adults. J Bone Miner Res. Published 2 February 2025. doi:10.
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