Variation in bone mineral density and fractures over 20 years among Canadians: a comparison of the Canadian Multicenter Osteoporosis Study and the Canadian Longitudinal Study on Aging
Authors' conclusion
Higher BMD and lower fracture prevalence were noted in the more recently recruited CLSA cohort compared to CaMos, even after adjusting for multiple covariates.
Study context
- Population
- Canadian men and women aged 50–85 years
- Participants
- 6,479 vs 19,534
- Exposure
- Canadian Multicentre Osteoporosis Study (CaMos) vs Canadian Longitudinal Study on Aging (CLSA)
- CaMosn = 6,479
- CLSAn = 19,534reference
- Outcome
- Sex-specific FN-BMD and prevalent major osteoporotic fractures (MOF)
Methodological detailstwo cohorts recruited 20 years apart, adjusted linear and logistic regression
- Two cohorts recruited 20 years apart
- Adjusted linear and logistic regression
Main finding
As reported in the abstract
CaMos vs CLSAEstimate (95% CI)
Women
aOR for prevalent MOF, women 1.99(1.71–2.30)
Men
aOR for prevalent MOF, men 2.33(1.82–3.00)
- Women
- adjusted difference in femoral neck bone mineral density (FN-BMD), women - 0.017 g/cm² (95% CI - 0.021; - 0.014)
- Men
- adjusted difference in FN-BMD, men - 0.006 g/cm² (95% CI - 0.011; 0.000)
Observational data: associations, not effects.
Further findings
Age at baseline
Menopausal hormone therapy use, women with prevalent MOF · similar in both cohorts
P = 0.076
Supplement use, women with prevalent MOF
P < 0.001
Bisphosphonate use, women with prevalent MOF
P < 0.001
- Baseline BMI and smoking · CaMos: lower mean BMI and higher smoking prevalence
- P < 0.001
Bisphosphonate use, men with major osteoporotic fractures (MOF)
- Below 10% in both cohorts
Original publication
Variation in bone mineral density and fractures over 20 years among Canadians: a comparison of the Canadian Multicenter Osteoporosis Study and the Canadian Longitudinal Study on Aging. Osteoporos Int. Published 30 November 2022. doi:10.
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