Geographic variation in bone mineral density and prevalent fractures in the Canadian longitudinal study on aging
Authors' conclusion
Geographical variations in total hip aBMD and in the prevalence of MOF between provinces persisted after adjusting for important covariates which suggests an association with unmeasured individual and environmental factors.
Study context
- Population
- Canadians aged 50–85 years in the Canadian Longitudinal Study on Aging (CLSA) (baseline 2012–2015); mean (SD) age 63.9 (9.1) years10,716 women · 10,511 men
- Participants
- 21,227 participants
- Exposure
- Canadian provinces of residence vs Ontario
- Outcome
- Sex-specific total hip aBMD and self-reported prevalent major osteoporotic fractures (MOF) by province
Methodological detailsbaseline data of the CLSA, sex-stratified linear and logistic regression, CLSA sampling weights
- Baseline data of the CLSA
- Sex-stratified linear and logistic regression
- CLSA sampling weights
Main finding
As reported in the abstract
Prevalent MOF by province (adjusted)
Each group vs ontarioAdjusted odds ratio (95% CI)P value
British Columbiawomen
0.47(0.32–0.69)
P < 0.03Quebecwomen
0.68(0.48–0.97)
P < 0.03British Columbiamen
0.40(0.22–0.71)
P < 0.03- Adjusted total hip aBMD lower than Ontario in women and men from British Columbia and Alberta, and in women from Manitoba and Nova Scotia
- P < 0.02
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| Recent falls (proportion of participants) | Alberta 12.0% · Manitoba 8.4% |
| Mean BMI (kg/m²) | British Columbia mean 27.4 (SD 5.0) kg/m² · Newfoundland and Labrador mean 28.8 (SD 5.3) kg/m² |
- Recent falls (proportion of participants) — Alberta highest, Manitoba fewest
- p-value=0.002
Mean BMI (kg/m²)
- Lowest in British Columbia, highest in Newfoundland and Labrador
Original publication
Geographic variation in bone mineral density and prevalent fractures in the Canadian longitudinal study on aging. Osteoporos Int. Published 2 December 2023. doi:10.
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