Validation of the 2024 European Association for the Study of Obesity diagnostic criteria: A comprehensive assessment of obesity‐related mortality risks
Authors' conclusion
This study confirms the prognostic value of the new obesity diagnostic criteria proposed by EASO, suggesting that these criteria offer a more accurate assessment of obesity-related health risks.
Study context
- Population
- NHANES participants 1999–2018; mean age 43.6 years, 51.3% male3,708 deaths
- Participants
- 39,066 participants
- Exposure
- New European Association for the Study of Obesity (EASO) obesity criteria vs traditional body mass index (BMI) ≥30 kg/m² criterion
- Outcome
- Associations between obesity and mortality (all-cause, CVD, cancer)
- Follow-up
- Median 141 months
Methodological detailsNHANES 1999-2018, Cox proportional hazards regression, mediation analysis
- NHANES 1999-2018
- Cox proportional hazards regression
- Mediation analysis
Main finding
As reported in the abstract
| Group | Value | Obesity prevalence | C-index | HR all-cause mortality (95% CI) | HR cardiovascular disease (CVD) mortality (95% CI) | HR cancer mortality (95% CI) | Obesity rate |
|---|---|---|---|---|---|---|---|
| EASO criteria | 63.04% | 63.04% | 0.5549 | 1.13 [1.02, 1.24] | 1.48 [1.20, 1.83] | 1.26 [1.03, 1.54] | |
| BMI ≥30 | 35.55% | 0.5265 | 35.55% |
Value
EASO criteria63.04%
BMI ≥3035.55%
Obesity prevalence
EASO criteria63.04%
BMI ≥30— not stated in the abstract
C-index
EASO criteria0.5549
BMI ≥300.5265
HR all-cause mortality (95% CI)
EASO criteria1.13 [1.02, 1.24]
BMI ≥30— not stated in the abstract
HR cardiovascular disease (CVD) mortality (95% CI)
EASO criteria1.48 [1.20, 1.83]
BMI ≥30— not stated in the abstract
HR cancer mortality (95% CI)
EASO criteria1.26 [1.03, 1.54]
BMI ≥30— not stated in the abstract
Obesity rate
EASO criteria— not stated in the abstract
BMI ≥3035.55%
Observational data: associations, not effects.
Further findings
Simplified criteria: BMI ≥25 kg/m², waist-to-height ratio (WtHR) ≥0.5 and any of top five complications (DM, hypertension, CVD, metabolic syndrome, ageing)
- C-index (highest)
- 0.612
- HR all-cause mortality
- 1.41 [1.26, 1.58] (95% CI)
- HR CVD mortality
- 2.08 [1.61, 2.68]
- HR cancer mortality
- 1.32 [1.06, 1.65]
Original publication
Validation of the 2024 European Association for the Study of Obesity diagnostic criteria: A comprehensive assessment of obesity‐related mortality risks. Diabetes Obes Metab. Published 14 February 2025. doi:10.
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