Use of Data Mining in the Establishment of Reference Intervals for Albumin‐Adjusted Calcium
Authors' conclusion
Our study reveals that albumin-adjusted calcium reference intervals are age-dependent, with slightly higher upper limits (≈0.05 mmol/L) than traditionally used total calcium ranges, potentially reducing overdiagnosis of hypercalcemia. Further studies are needed to validate these reference intervals across different automated analyzers and diverse patient populations to ensure broader clinical applicability.
Study context
- Population
- Individuals aged 18–80 years, selected from 106,920 patients by biochemical and clinical exclusion criteria, high-volume tertiary care laboratoryfrom 106,920 patients
- Participants
- 33,159 individuals
- Exposure
- 18-49 years vs 50-79 years
- Outcome
- Reference intervals for albumin-adjusted calcium (2.5th–97.5th percentiles)
Methodological detailsreal-world laboratory data, single high-volume tertiary care laboratory, age-partitioned, 2.5th and 97.5th percentiles
- Real-world laboratory data
- Single high-volume tertiary care laboratory
- Age-partitioned
- 2.5th and 97.5th percentiles
Main finding
As reported in the abstract
Albumin-adjusted calcium reference interval
18-49 years
2.17-2.55
reference interval · mmol/L
50-79 years
2.20-2.61
reference interval · mmol/L
Observational data: associations, not effects.
Further findings
| Outcome | 18-49 years | 50-79 years |
|---|---|---|
| Total calcium reference interval | reference interval 2.17-2.56 mmol/L | reference interval 2.17-2.62 mmol/L |
Original publication
Use of Data Mining in the Establishment of Reference Intervals for Albumin‐Adjusted Calcium. Clin Endocrinol (Oxf). Published 4 June 2025. doi:10.
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