Urinary metabolomics provide insights into coronary artery disease in individuals with type 1 diabetes
Authors' conclusion
We have performed the first high-throughput urinary metabolomics analysis on CAD in individuals with type 1 diabetes and found xanthosine, 3-hydroxyisobutyrate, trans-aconitate, and 4-deoxythreonate to be associated with incident CAD. In addition, metabolomic state profiling improved prediction of incident CAD.
Study context
- Population
- Adults with T1D from the Finnish Diabetic Nephropathy Study209 incident coronary artery disease (CAD)
- Participants
- 2,501 adults
- Outcome
- Incident CAD
- Follow-up
- 10-year follow-up
Methodological detailshigh-throughput targeted urine metabolomics, metabolome-wide survival analyses, correlation network analyses, metabolomic state profiling, Baseline urine analysed on a targeted metabolomics platform yielding 54 metabolites
- High-throughput targeted urine metabolomics
- Metabolome-wide survival analyses
- Correlation network analyses
- Metabolomic state profiling
- Baseline urine analysed on a targeted metabolomics platform yielding 54 metabolites
Main finding
As reported in the abstract
Urinary metabolites associated with incident CAD
- Urinary 3-hydroxyisobutyrate associated with decreased 10-year incident CAD (likely reflecting younger age and improved kidney function)
- Urinary xanthosine associated with 10-year incident CAD; correlated with baseline urinary allantoin, a marker of oxidative stress
- Urinary trans-aconitate and 4-deoxythreonate associated with decreased 5-year incident CAD
Observational data: associations, not effects.
Further findings
Prediction of incident CAD by metabolomic state profiling
- CAD-associated urinary metabolites improved prediction accuracy, especially during shorter follow-up
Network analysis: GFR
- GFR suggested to influence the urinary metabolome differently between individuals with and without future CAD
Original publication
Urinary metabolomics provide insights into coronary artery disease in individuals with type 1 diabetes. Cardiovasc Diabetol. Published 26 November 2024. doi:10.
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