Untargeted metabolomics and mendelian randomization analysis identify adrenic acid as a novel biomarker of Type 2 diabetes mellitus
Authors' conclusion
Increased plasma AdA level was associated with higher FBG and an elevated risk of T2DM, suggesting that AdA represents a probable biomarker for T2DM.
Study context
- Population
- Chinese participants with T2D and controls
- Participants
- 120 participants
- Comparison
- T2D patients vs controls
- T2Dn = 60
- Controln = 60reference
- Outcome
- T2D-associated metabolic biomarkers
Methodological detailsUHPLC-MS/MS plasma metabolomics, orthogonal partial least squares discriminant analysis (OPLS-DA)
- UHPLC-MS/MS plasma metabolomics
- OPLS-DA
Main finding
As reported in the abstract
Up-regulated metabolites in T2D patients
71
Down-regulated metabolites in T2D patients
37
Metabolites with causal associations with T2D risk in MR analysis
52
Observational data: associations, not effects.
Further findings
Main impacted metabolic pathways
- Unsaturated fatty acids biosynthesis and linoleic acid metabolism
Original publication
Untargeted metabolomics and mendelian randomization analysis identify adrenic acid as a novel biomarker of Type 2 diabetes mellitus. Diabetes Res Clin Pract. Published 1 May 2026. doi:10.
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