Uncovering covariance patterns across energy balance traits enables the discovery of new obesity‐related genes
Authors' conclusion
We offer new insight into EB patterns and the genetic basis of EB.
Study context
- Population
- UK Biobank participants with numerous energy balance-related traits (body size and composition, diet, physical activity, metabolic profile)
- Outcome
- Genes and genomic regions associated with energy balance
Methodological detailssparse factor analysis, pleiotropy analyses, independent validation
- Sparse factor analysis
- Pleiotropy analyses
- Independent validation
Performance
As reported in the abstract
- Multiple genes and genomic regions associated with energy balance (EB) identified, incl. many not previously directly associated with obesity measures (e.g., MIR5591, FNDC3B, ANAPC10, SULT1A1, AXIN1, SKIDA1, ERLIN1, DOCK7)
- Validated in an independent UK Biobank subset and the Atherosclerosis Risk in Communities cohort
- Covariances in EB traits primarily driven by genome-wide pleiotropic associations
Original publication
Uncovering covariance patterns across energy balance traits enables the discovery of new obesity‐related genes. Obesity (Silver Spring). Published 26 May 2025. doi:10.
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