U-shaped association between triglyceride-glucose index and all-cause mortality among critically ill pediatrics: a population-based retrospective cohort study
Authors' conclusion
Our study showed that the association between the TyG index and 30-day in-hospital and in-ICU all-cause mortality was nonlinear U-shaped, with a cutoff point at the TyG index of 8.6 in critically ill pediatric patients. Our findings suggest that the TyG index may be a novel and important factor for the short-term clinical prognosis in pediatric patients.
Study context
- Population
- Critically ill pediatric patients in the Pediatric Intensive Care database; median age 20.5 (IQR 4.8, 63.0) months, 57.3% male; mean triglyceride-glucose (TyG) index 8.6 ± 0.7
- Participants
- 5,706 patients
- Exposure
- TyG index <8.6 vs ≥8.6
- Outcome
- 30-day in-hospital all-cause mortality
- Follow-up
- 30 days
Methodological detailspopulation-based
- Population-based
Main finding
As reported in the abstract
Estimate (95% CI)
TyG < 8.6risk negatively correlated with TyG index below 8.6
aHR (per TyG index, until it bottoms out at 8.6) 0.72(0.55–0.93)
TyG ≥ 8.6risk increased significantly above 8.6
aHR (TyG index higher than 8.6) 1.51(1.16–1.96)
- Died within 30 days of hospitalization
- 244 (4.3%)
- U-shaped association between TyG index and mortality (restricted cubic spline (RCS))
- P values for non-linear < 0.001
Observational data: associations, not effects.
Secondary outcomes
30-day in-ICU all-cause mortality
| aHR (95% CI) | ||
|---|---|---|
| TyG < 8.6 | 0.75 (0.57–0.98) | |
| TyG ≥ 8.6 | 1.42 (1.08–1.85) | |
| 0.512Adjusted hazard ratio (log scale) |
- 30-day in-ICU all-cause mortality — Died in intensive care unit (ICU) within 30 days of hospitalization
- 236 (4.1%)
- 30-day in-ICU all-cause mortality — U-shaped association between TyG index and mortality (RCS)
- P values for non-linear < 0.001
- 30-day in-ICU all-cause mortality: median follow-up 6 [3, 11] days
Subgroup and sensitivity analyses
- Results consistent in subgroups and various sensitivity analyses
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
U-shaped association between triglyceride-glucose index and all-cause mortality among critically ill pediatrics: a population-based retrospective cohort study. Cardiovasc Diabetol. Published 26 June 2024. doi:10.
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