Type 2 diabetes and cardiorenal syndromes. A nationwide French hospital cohort study
Authors' conclusion
Patients with T2DM represent almost half of patients with CRS and are younger than their non-diabetic counterparts. T2DM doubles the risk of CRS and increases the risk of death, cardiovascular outcome, and end-stage kidney disease but not ischemic stroke after CRS.
Study context
- Population
- Adults hospitalized in France in 2012 with ≥5 years of follow-up, without cardiorenal syndromematched cohort
- Participants
- 5,123,193 adults
- Exposure
- T2D vs no T2D
- T2DMn = 380,581
- Without T2DMn = 380,581reference
- Outcome
- Incident cardiorenal syndrome (CRS; cardiorenal, renocardiac and simultaneous subtypes)
Methodological details1:1 propensity matching
- 1:1 propensity matching
Main finding
As reported in the abstract
Incident CRS
T2D
1.30%/year
No T2D
0.65%/year
Estimate (95% CI)
T2Dvs No T2D
aHR, any CRS 2.14(2.10–2.19)
T2Dvs No T2D
aHR, renocardiac 2.43(2.34–2.53)
T2Dvs No T2D
aHR, cardiorenal 2.09(2.03–2.15)
T2Dvs No T2D
aHR, simultaneous 1.94(1.86–2.03)
- Cardiorenal syndrome (CRS) occurred during follow-up
- 104,788 patients
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Outcomes after prevalent CRS in 2012 (8,314 T2D matched to 8,314 without)T2Dvs No T2D | aHR, end-stage kidney disease 1.50 (CI 1.39–1.62) | |
| Outcomes after prevalent CRS in 2012 (8,314 T2D matched to 8,314 without)T2Dvs No T2D | aHR, MI 1.35 (CI 1.19–1.53) | |
| Outcomes after prevalent CRS in 2012 (8,314 T2D matched to 8,314 without)T2Dvs No T2D | aHR, cardiovascular death 1.20 (CI 1.13–1.27) | |
| Outcomes after prevalent CRS in 2012 (8,314 T2D matched to 8,314 without)T2Dvs No T2D | aHR, HF 1.17 (CI 1.12–1.21) | |
| Outcomes after prevalent CRS in 2012 (8,314 T2D matched to 8,314 without)T2Dvs No T2D | aHR, all-cause death 1.09 (CI 1.06–1.13) | |
| 0.512Ratio (log scale) |
Outcomes after prevalent CRS in 2012 (8,314 T2D matched to 8,314 without)
- No increased risk of ischemic stroke
T2D among adults with CRS in 2012
- Adults with CRS who had T2D (of 26,396)
- 11,355 (43.0%)
- Age, T2D vs non-diabetic
- 77.4 ± 9.5 versus 82.3 ± 10.0
Original publication
Type 2 diabetes and cardiorenal syndromes. A nationwide French hospital cohort study. Diabetes Metab. Published 15 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →