Tumor Volume Doubling Time of Less Than 1 Year Is Associated With a Higher Risk of Death From Medullary Thyroid Cancer
Authors' conclusion
Measurements from 3 baseline and 3 most recent scans preceding follow-up visit enable calculation of TVDT and can be used as predictors of mortality from MTC.
Study context
- Population
- Patients with metastatic hereditary or sporadic medullary thyroid cancer (MTC) with at least 3 consecutive imaging studies; median age 19 years (IQR, 15–41), 53% female
- Participants
- 51 patients286 metastatic lesions
- Exposure
- Tumor volume doubling time (TVDT) <1 year vs longer TVDT
- Outcome
- Disease-specific survival (DSS) by TVDT
Main finding
As reported in the abstract
Factors independently associated with shorter DSS · follow-up 51 (IQR, 25-102) months
- TVDT <1 year based on 3 initial and 3 last scans independently associated with shorter disease-specific survival (DSS)
- Lung, brain and prostate as organs with fastest growing tumor independently associated with shorter DSS
- Cox proportional regression model
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Cumulative metastatic volumes and proportion with TVDT <1 year, sporadic vs hereditary MTCHigher with sporadic | P < 0.01 |
Correlation of TVDT based on 2-dimensional and 3-dimensional measurements
- Strong correlation, r (P < .05)
- 0.94
Original publication
Tumor Volume Doubling Time of Less Than 1 Year Is Associated With a Higher Risk of Death From Medullary Thyroid Cancer. J Clin Endocrinol Metab. Published 16 October 2024. doi:10.
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