Tumor-infiltrating T Lymphocytes Recognize Thyroid-specific Proteins and Neo-antigens in Follicular Cell-derived Thyroid Cancers
Authors' conclusion
Our studies confirm the presence of tumor antigen-specific T cells in patients with thyroid cancer and encourage further exploration of T cell-targeted immunotherapies for patients with progressive, treatment refractory thyroid cancer.
Study context
- Population
- Patients with follicular cell-derived thyroid cancer; Tumor-infiltrating lymphocytes (TIL) expanded from primary thyroid tumors and tumor-involved lymph nodes (TILN)
- Outcome
- Tumor antigen-specific T-cell reactivity
Main finding
As reported in the abstract
Shared clones in primary tumors and matched TILN in all patients tested; 1% to 10% of sequenced clones
6/8 patients
T-cell reactivity to thyroid peroxidase
84.6%
11/13
T-cell reactivity to thyroglobulin
69.2%
9/13
BrafV600E-specific T-cell response in BrafV600E+ patients
80%
4/5
Original publication
Tumor-infiltrating T Lymphocytes Recognize Thyroid-specific Proteins and Neo-antigens in Follicular Cell-derived Thyroid Cancers. J Clin Endocrinol Metab. Published 22 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →