Impact of sex hormones on pheochromocytomas, paragangliomas, and gastroenteropancreatic neuroendocrine tumors
Authors' conclusion
We provide novel data on the effects of elevated sex hormone levels, potentially seen during pregnancy or hormone replacement therapy, on PPGL/GEP-NET tumor growth. G-1 might offer a novel therapeutic approach for some PPGLs depending on patient's sex and the individual tumor's genetic/molecular background. All HNPGLs showed ERα positivity.
Study context
- Population
- Human patient-derived PPGL and GEP-NET primary cultures and PPGL tumor tissues
- Comparison
- Estradiol, progesterone, Dehydroepiandrosterone sulfate (DHEAS), testosterone and GPER agonist G-1 on PPGL/GEP-NET primary culture cell viability
- Outcome
- Primary culture cell viability
Methodological detailspatient-derived primary cell cultures, next-generation sequencing, immunohistochemistry
- Patient-derived primary cell cultures
- Next-generation sequencing
- Immunohistochemistry
Main finding
As reported in the abstract
PPGL/GEP-NET primary culture cell viability
DHEAS and testosterone (1 µm) showed no effects; testosterone (10 µm) showed significant antitumor effects, including a pheochromocytoma lung metastasis with strong androgen receptor positivity
30%
Further findings
ERα positivity in PPGL tissues
- ERα-positive pheochromocytomas and paragangliomas (PPGLs)
- 11/36
- ERα-positive head-and-neck paragangliomas (HNPGLs)
- 4/4
Original publication
Impact of sex hormones on pheochromocytomas, paragangliomas, and gastroenteropancreatic neuroendocrine tumors. Eur J Endocrinol. Published 10 January 2025. doi:10.
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