TSH ≥30 mU/L may not be necessary for successful 131I remnant ablation in patients with differentiated thyroid cancer
Authors' conclusion
TSH ≥ 30 mU/L may not be necessary for the success of RRA. Patients with higher serum TSH levels prior to RRA will suffer from severer hyperlipidemia. Pre-Tg level could be used as a predictor for the success of RRA, especially when TSH < 30 mU/L.
Study context
- Population
- Patients with differentiated thyroid cancer (DTC) undergoing radioiodine (131I) remnant ablation (RRA)
- Participants
- 487 patients
- Exposure
- TSH ≥30 vs <30 mU/L before RAI remnant ablation
- Outcome
- Success rate of RRA
Main finding
As reported in the abstract
- No statistical difference in RRA success rates across eight TSH subgroups (0-<30 to 90-<100 mU/L)
- P = 0.685
Observational data: associations, not effects.
Further findings
Serum lipids, TSH ≥30 vs <30 mU/L
- Total cholesterol significantly higher at TSH ≥30
- P < 0.001
- TG significantly higher at TSH ≥30
- P = 0.006
- HDL-C significantly higher at TSH ≥30
- P = 0.024
- LDL-C significantly higher at TSH ≥30
- P = 0.001
- Apolipoprotein B significantly higher at TSH ≥30
- P < 0.001
- Apolipoprotein E significantly higher at TSH ≥30
- P = 0.002
- apoA/apoB ratio significantly lower at TSH ≥30
- P = 0.024
Influencing factors for RRA
- Pre-Tg level, gender and N stage were influencing factors for RRA
Prediction of RRA success (AUC)
- Pre-Tg AUC, all patients
- 0.7611 (P < 0.0001)
- Pre-Tg/TSH ratio AUC, all patients
- 0.7340 (P < 0.0001)
- Pre-Tg AUC, TSH < 30 mU/L
- 0.7310 (P = 0.0145)
- Pre-Tg/TSH ratio AUC, TSH < 30 mU/L
- 0.6524 (P = 0.1068)
Original publication
TSH ≥30 mU/L may not be necessary for successful 131I remnant ablation in patients with differentiated thyroid cancer. Eur Thyroid J. Published 12 June 2023. doi:10.
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