tRNA‐derived fragments are altered in diabetes
Authors' conclusion
This is the first report showing altered serum levels of tiRNAs in diabetes subjects. The combined use of 5'ValCAC and miR-23b-3p as serum biomarkers could potentially differentiate between MIDD subjects and type 2 diabetes subjects.
Study context
- Population
- Serum samples from healthy controls and subjects with T1D, T2D and maternally inherited diabetes and deafness (MIDD)
- Comparison
- Serum tiRNA 5'ValCAC and miR-23b-3p in MIDD, T1D and T2D vs healthy controls
- Outcome
- Serum levels of tiRNA 5'ValCAC (alone and combined with miR-23b-3p)
Main finding
As reported in the abstract
Serum 5'ValCAC
- Serum 5'ValCAC reduced in MIDD and T2D vs controls
Observational data: associations, not effects.
Further findings
Serum miR-23b-3p
- T2D had higher serum miR-23b-3p than all other subjects
ROC analysis for MIDD
- 5'ValCAC and miR-23b-3p showed potential as MIDD biomarkers; combination showed excellent separation from T2D
Original publication
tRNA‐derived fragments are altered in diabetes. Diabet Med. Published 20 November 2023. doi:10.
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