Triglyceride glucose-waist height ratio index is a promising and robust glucose and lipid metabolism indicator for predicting long-term type 2 diabetes: insights from a Japanese prospective cohort data from 12 years
Authors' conclusion
TyG-WHtR is a promising and robust indicator for predicting the long-term risk of T2D in the general population, enables the detection of T2D high-risk individuals, and offers personalized and accurate risk stratification.
Study context
- Population
- Japanese general population cohort
- Participants
- 15,453 participants
- Exposure
- 16 glucose and lipid metabolism indicators for predicting T2D
- Outcome
- Predictive value of indicators for incident T2D (ROC AUC)
- Follow-up
- Maximum 12 years
Methodological detailsmaximum follow-up of 12 years
- Maximum follow-up of 12 years
Main finding
As reported in the abstract
Prediction of T2D
| Group | AUC |
|---|---|
| TyG-WHtR | 0.786 |
TyG-WHtR
AUC0.786
- TyG-WHtR had the highest AUC of the 16 indicators
- 0.786
Observational data: associations, not effects.
Further findings
T2D incidence, fully adjusted multivariable Cox model
- HR for TyG-WHtR
- 2.99 (95% CI 2.45, 3.65)
Robustness: subgroup ROC and TimeROC · 1 to 12 years
- TyG-WHtR maintained excellent and sustained predictive capability across different populations and times
Original publication
Triglyceride glucose-waist height ratio index is a promising and robust glucose and lipid metabolism indicator for predicting long-term type 2 diabetes: insights from a Japanese prospective cohort data from 12 years. Diabetes Res Clin Pract. Published 30 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →