The triglyceride-glucose index, ventricular arrhythmias and major cardiovascular events in patients at high risk of sudden cardiac death
Authors' conclusion
In our cohort, the pre-operational TyG index is significantly associated with VAs and major cardiovascular events for patients with high risk of SCD.
Study context
- Population
- Patients at high risk of sudden cardiac death (SCD) with an indication for implantable cardioverter-defibrillator (ICD) implantation, Chinese National Center for Cardiovascular Diseases; mean age 59.6 ± 14.0 years, 25.7% female
- Participants
- 1,046 patients
- Exposure
- Triglyceride-glucose (TyG) index
- Outcome
- VAs: sustained ventricular tachycardia and ventricular fibrillation documented by the ICD
- Follow-up
- Mean 36.1 months
Main finding
As reported in the abstract
VAs
Hazard ratio (95% CI)
Per 1 TyG indexFine-Gray subdistribution hazard model
2.95(2.29–3.80)
Highest tertilevs Lowest tertile
4.08(2.81–5.92)
- Patients with ventricular arrhythmias (VAs)
- 342 (32.7%)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| Secondary outcome: cardiac mortality, heart transplantation, rehospitalization for HF · mean follow-up 36.1 monthsPer 1 TyG index · Fine-Gray subdistribution hazard model | 2.84 (1.86–4.34) | |
| Secondary outcome: cardiac mortality, heart transplantation, rehospitalization for HF · mean follow-up 36.1 monthsHighest tertilevs Lowest tertile | 3.18 (1.73–5.85) | |
| 0.20.5125Hazard ratio (log scale) |
- Secondary outcome: cardiac mortality, heart transplantation, rehospitalization for HF — Patients with major cardiovascular events
- 185 (17.7%)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The triglyceride-glucose index, ventricular arrhythmias and major cardiovascular events in patients at high risk of sudden cardiac death. Cardiovasc Diabetol. Published 28 October 2024. doi:10.
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