Comprehensive echocardiographic and biomarker assessment of patients with diabetic ketoacidosis
Authors' conclusion
Diabetic ketoacidosis induces changes in the structure and function of the heart, which are mostly transient, reflect the presence of a hyperdynamic state and resolve after the resolution of the episode. Some subjects present with evidence of myocardial injury with elevated cardiac troponin and left ventricular dysfunction.
Study context
- Population
- Subjects with an episode of diabetic ketoacidosis (DKA); mean age 33 ± 13.6 years, 70% female, 70% T1D; 75% severe, rest moderate episodes
- Participants
- 20 subjects
- Exposure
- During DKA vs after DKA resolution
- Outcome
- Cardiac structure and function by TTE during vs after DKA
Main finding
As reported in the abstract
- LV volumes and diameters increased significantly after DKA resolution
- No difference in left ventricular ejection fraction (LVEF) or global longitudinal strain (GLS) during vs after DKA resolution
- During DKA vs After DKA resolution: P = < 0.001
- During DKA vs After DKA resolution: LV ejection time shorter during DKA: 218.6 ± 37.9 vs 265.06 ± 34.7
- During DKA vs After DKA resolution: P = < 0.001
Observational data: associations, not effects.
Further findings
- LV dysfunction
- 35%
- LV dysfunction both in GLS and LVEF
- 28.5%
- Occurred after DKA resolution, with alterations in GLS
- 28.5%
Safety
Troponin elevation (myocardial injury) · first 24 h after admission
- Participants with troponin elevations (half moderate, half severe episodes)
- 20%
Original publication
Comprehensive echocardiographic and biomarker assessment of patients with diabetic ketoacidosis. Cardiovasc Diabetol. Published 28 October 2024. doi:10.
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