Lipids & metabolic liver disease
Triglyceride-glucose index, renal function and cardiovascular disease: a national cohort study
Main finding · Cardiovascular diseasesResult — go to the resultHazard ratio 1.870 95% CI 1.131–3.069Authors' conclusion
The combination of a higher TyG index and lower eGFR level was associated with the highest risk of cardiovascular diseases. Renal function could mediate the association between the TyG index and cardiovascular risk.
Study context
- Population
- Participants of the China Health and Retirement Longitudinal Study (CHARLS) free of CVD at baseline; mean age 59.6 ± 9.5 years, 46.1% females
- Participants
- 6,496 participants
- Exposure
- Higher triglyceride-glucose (TyG) index and decreased estimated glomerular filtration rate (eGFR) vs lower TyG index and eGFR ≥ 60 ml/minute/1.73 m²
- Outcome
- Cardiovascular diseases
- Follow-up
- Maximum 7.0 years
Methodological detailsnational cohort, mediation analysis, Cox models
- National cohort
- Mediation analysis
- Cox models
Main finding
As reported in the abstract
Hazard ratio
1.870
95% CI 1.131–3.069
Higher TyG index and decreased eGFRvs Lower TyG index and eGFR ≥ 60
HR 1.870 (95% CI 1.131–3.069)
- Decreased eGFR mediated proportion of the TyG index–CVD association
- 29.6%
Observational data: associations, not effects.
Further findings
Incident CVD, heart diseases and stroke (whole cohort) · maximum follow-up 7.0 years
- Developed CVD
- 1 996 (30.7%)
- Heart diseases
- 1 541 (23.7%)
- Stroke
- 651 (10.0%)
Original publication
Triglyceride-glucose index, renal function and cardiovascular disease: a national cohort study. Cardiovasc Diabetol. Published 28 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →