Triglyceride glucose index predicts long-term mortality and major adverse cardiovascular events in patients with type 2 diabetes
Main finding · All-cause mortality per TyG indexResult — go to the resultHazard ratio 1.39 95% CI 1.07–1.79Authors' conclusion
The TyG index is a valuable prognostic marker for long-term risk of all-cause mortality and MACE in patients with T2D, supporting its use in clinical risk stratification.
Study context
- Population
- Patients with T2D (median age 67 years, IQR 61–72; 54% males; median disease duration 14 years; median HbA1c 7.3%) and presumably healthy controls (median age 65 years)
- Participants
- 568 vs 376
- Exposure
- TyG index as predictor of outcomes in T2D; T2D vs healthy controls
- T2Dn = 568
- Controls (CTR)n = 376reference
- Outcome
- All-cause mortality and MACE
- Follow-up
- Median 16.8 (IQR, 13.1-16.8) years
Main finding
All-cause mortality per TyG index
Hazard ratio
1.39
95% CI 1.07–1.79
TyG index
HR 1.39 (95% CI 1.07–1.79)
Per TyG index, as printed
As reported in the abstract
Observational data: associations, not effects.
Further findings
TyG index T2D vs CTR · baseline
- T2D had higher TyG index than CTR
- Higher baseline TyG index with preexisting diabetic kidney disease (DKD) or atherosclerotic vascular disease
- Sex-specific differences among CTR but not in T2D
Age effect modification of TyG–mortality association
- Age modified the association; strongest effect at ages 57-74
Original publication
Triglyceride glucose index predicts long-term mortality and major adverse cardiovascular events in patients with type 2 diabetes. Cardiovasc Diabetol. Published 10 March 2025. doi:10.
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