Triglyceride glucose index in patients with acute coronary syndrome undergoing percutaneous coronary intervention predicts cardiovascular events: a cohort study
Main finding · MACEResult — go to the resultHazard ratio 1.246 95% CI 1.064–1.459Authors' conclusion
Our findings underscore a significant association between the TyG index and adverse cardiovascular outcomes, including cardiovascular and all-cause mortality, in ACS patients following PCI. The TyG index may thus function as an early predictor of cardiovascular risk or a potential therapeutic target in the management of cardiovascular disease.
Study context
- Population
- Patients with acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI), COSTIC registry
- Participants
- 8,019 patients
- Exposure
- Triglyceride-glucose (TyG) index per IQR increment
- Outcome
- MACE: cardiovascular death, all-cause death, MI and stroke
- Follow-up
- 1 year
Methodological detailsobservational, single-centre
- Observational
- Single-centre
Main finding
MACE · 1-year follow-up
Hazard ratio
1.246
95% CI 1.064–1.459
P = 0.006
TyG index per IQR increment
HR 1.246 (95% CI 1.064–1.459); P = 0.006
Per IQR increment, as printed
As reported in the abstract
- Major adverse cardiovascular events (MACEs) documented
- 341
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Cardiovascular death · 1-year follow-up | 1.409 (1.150–1.727) | P = 0.001 | |
| All-cause death · 1-year follow-up | 1.368 (1.133–1.652) | P = 0.001 | |
| 0.512Hazard ratio (log scale) |
- Cardiovascular death — Cardiovascular deaths
- 197
- All-cause death — All-cause deaths
- 242
Cardiovascular death · 1-year follow-up
- No non-linear relationship (p-non-linear = 0.684)
All-cause death · 1-year follow-up
- No non-linear relationship (p-non-linear = 0.827)
Stratified analyses
- Significant interactions between TyG index and sex, smoking status and ACS diagnosis (p for interaction < 0.05)
Original publication
Triglyceride glucose index in patients with acute coronary syndrome undergoing percutaneous coronary intervention predicts cardiovascular events: a cohort study. Cardiovasc Diabetol. Published 1 October 2025. doi:10.
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