Association between metabolic score for insulin resistance and future stroke risk in patients with cardiovascular-kidney-metabolic syndrome stages 0–3: a longitudinal analysis based on China Health and Retirement Longitudinal Study (CHARLS)
Authors' conclusion
In individuals with CKM syndrome stages 0-3, elevated METS-IR levels may be associated with an increased stroke risk. Furthermore, METS-IR demonstrates moderate predictive value for stroke risk in this population. Monitoring METS-IR may therefore aid in their early identification.
Study context
- Population
- Individuals with cardiovascular-kidney-metabolic (CKM) syndrome stages 0–3 without stroke at baseline, China Health and Retirement Longitudinal Study (CHARLS); mean age 60.48 ± 8.81 years
- Participants
- 5,009 individuals
- Exposure
- Metabolic score for insulin resistance (METS-IR) quartiles Q2–Q4 vs Q1
- Outcome
- Self-reported stroke
- Follow-up
- 5-year follow-up
Methodological detailslongitudinal, CHARLS-based
- Longitudinal
- CHARLS-based
Main finding
As reported in the abstract
Incident stroke
Odds ratio (95% CI)P value
Q3vs Q1
1.88(1.25–2.81)
P = 0.002Q4vs Q1
1.72(1.08–2.76)
P = 0.02- Participants developing incident stroke
- 339
Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic spline (RCS)) of METS-IR with stroke risk
- Nonlinear relationship between METS-IR and stroke risk
- P-overall < 0.05; P-nonlinearity < 0.05
Predictive value of METS-IR for stroke (ROC)
- AUC
- 0.726 (95% CI 0.699-0.752)
- Optimal METS-IR cutoff
- 29.58
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between metabolic score for insulin resistance and future stroke risk in patients with cardiovascular-kidney-metabolic syndrome stages 0–3: a longitudinal analysis based on CHARLS. Cardiovasc Diabetol. Published 1 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →