Triglyceride-glucose index correlates with the incidences and prognoses of cardiac arrest following acute myocardial infarction: data from two large-scale cohorts
Authors' conclusion
Elevated TyG levels were found to apparently correlate with higher prevalence and adverse outcomes regarding CA in patients with AMI. Our findings point a fresh insight into the significance of the TyG in critically ill coronary conditions.
Study context
- Population
- Patients with acute myocardial infarction (AMI) for whom triglyceride-glucose (TyG) could be calculated within the first 24 h after admission (MIMIC-IV and eICU databases)371 developed cardiac arrest (CA)
- Participants
- 5,208 patients
- Exposure
- Higher vs lower TyG index
- CAn = 371
- Outcome
- In-hospital and ICU mortality
Methodological detailsmulticenter, MIMIC-IV and eICU databases, overlap weighting, inverse probability of treatment weighting (IPTW) and propensity score matching
- Multicenter
- MIMIC-IV and eICU databases
- Overlap weighting, IPTW and propensity score matching
Main finding
As reported in the abstract
TyG and in-hospital mortality, OR
1.711
TyG and ICU mortality, OR
1.520
Linear relationship of TyG with in-hospital and ICU mortality (restricted cubic splines (RCS)), P for nonlinearity
0.592 and 0.816
Observational data: associations, not effects.
Further findings
| Outcome | CA | Without CA |
|---|---|---|
| TyG in AMI with vs without CA | 9.2 (range 8.7–9.7) | 9.0 (range 8.5–9.4) |
TyG in AMI with vs without CA
- TyG showed moderate discriminatory capacity for CA occurrence in AMI
LOS
- TyG associated with prolonged LOS in AMI-CA
Subgroups
- Strong TyG–mortality link among elders, females, BMI < 28 kg/m² and hypertension
Original publication
Triglyceride-glucose index correlates with the incidences and prognoses of cardiac arrest following acute myocardial infarction: data from two large-scale cohorts. Cardiovasc Diabetol. Published 8 March 2025. doi:10.
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