Triglyceride-glucose index and mortality in critically ill patients with cardiovascular-kidney-metabolic syndrome stage 4
Main finding · 1-year all-cause mortalityResult — go to the resultHazard ratio 1.30 95% CI 1.08–1.55Authors' conclusion
These findings indicate that higher TyG levels are independently associated with increased short- and long-term mortality in critically ill patients with CKM stage 4.
Study context
- Population
- Critically ill patients with CKM stage 4 in the MIMIC-IV database; 65.22% male
- Participants
- 3,125 patients
- Exposure
- Triglyceride-glucose (TyG) index tertiles
- Outcome
- All-cause mortality
- Follow-up
- 1 year
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
1-year all-cause mortality
Hazard ratio
1.30
95% CI 1.08–1.55
By group
Q3vs Q1
HR 1.30 (95% CI 1.08–1.55)
As reported in the abstract
- 1-year all-cause mortality overall
- 34.18%
- Difference across tertiles
- P < 0.05
- HR per 1-SD increase in TyG index (multivariable Cox)
- 1.23 (95% CI 1.09-1.39)
Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic spline (RCS) analysis)
- Linear positive relationship between TyG index and mortality
- P for non-linearity > 0.05
Original publication
Triglyceride-glucose index and mortality in critically ill patients with cardiovascular-kidney-metabolic syndrome stage 4. Cardiovasc Diabetol. Published 24 March 2026. doi:10.
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