Triglyceride-glucose index and health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies
Authors' conclusion
We found that the TyG index was positively associated with many diseases including the risk of CIN and stroke, the prognosis of CAD, and the severity of CAD which were supported by moderate-quality evidence. TyG index might be useful to identify people at high-risk for developing these diseases.
Study context
- Population
- Meta-analyses of triglyceride-glucose (TyG) index and health outcomes; PubMed, EMBASE, Web of Science to 8 April 202495 associations · 29 meta-analyses
- Comparison
- Highest vs lowest category of the TyG index
- Outcome
- Associations between TyG index and 30 health outcomes
Methodological detailsAMSTAR quality assessment, Grading of Recommendations, Assessment, Development and Evaluation (GRADE) certainty assessment, random effects model
- AMSTAR quality assessment
- GRADE certainty assessment
- Random effects model
Pooled result
As reported in the abstract
Moderate-quality evidence
Each group vs lowest TyG index categoryEstimate (95% CI)
High TyG index
RR, CIN 2.25(1.82–2.77)
High TyG index
RR, stroke in DM 1.26(1.18–1.33)
High TyG index
RR, stroke in acute coronary syndrome 1.56(1.06–2.28)
High TyG index
RR, CAD prognosis: non-fatal MI 2.02(1.32–3.10)
High TyG index
RR, coronary artery stenosis 3.49(1.71–7.12)
High TyG index
RR, multi-vessel CAD 2.33(1.59–3.42)
- Statistically significant associations (P < 0.05, random effects model)
- 83 (87.4%)
- Associations supported by moderate-quality evidence (GRADE)
- 6 (6.3%)
- High-quality meta-analyses (AMSTAR); none low quality
- 16 (55.2%)
Original publication
Triglyceride-glucose index and health outcomes: an umbrella review of systematic reviews with meta-analyses of observational studies. Cardiovasc Diabetol. Published 23 May 2024. doi:10.
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