Association of prediabetes with clinical outcomes in patients with chronic coronary syndrome: a post hoc analysis of the ISCHEMIA and ISCHEMIA-CKD trials
Authors' conclusion
In patients with chronic coronary syndrome, diabetes but not prediabetes was associated with significantly increased risk of all-cause death within a median follow-up period of 3.1 years.
Study context
- Population
- Patients with chronic coronary syndrome determined by coronary CT angiography or exercise-stress testing, ISCHEMIA and ISCHEMIA-CKD trials
- Participants
- 3,910 patients
- Comparison
- Prediabetes and diabetes vs normoglycemia
- Normoglycemian = 716reference
- Prediabetesn = 911
- Diabetesn = 2,283
- Primary endpoint
- All-cause mortality
- Follow-up
- Median 3.1 years (IQR 2.1-4.1)
Methodological detailspost hoc analysis, covariate-adjusted Cox model
- Post hoc analysis
- Covariate-adjusted Cox model
Primary result
As reported in the abstract
median follow-up 3.1 years
Each group vs normoglycemiaAdjusted hazard ratio (95% CI)
Prediabetes
1.45(0.95–2.20)
Diabetes
1.84(1.29–2.65)
- Overall all-cause mortality
- 330 (8.4%) of 3910
Secondary outcomes
| Outcome | aHR (95% CI) | |
|---|---|---|
| StrokePrediabetesvs Normoglycemia | 3.44 (1.15–10.25) | |
| 0.050.21520Adjusted hazard ratio (log scale) |
All-cause death, subgroups (males; patients under 65 years)
- Subgroup analyses suggested an increased risk of all-cause death with prediabetes in males and patients under 65 years
Original publication
Association of prediabetes with clinical outcomes in patients with chronic coronary syndrome: a post hoc analysis of the ISCHEMIA and ISCHEMIA-CKD trials. Cardiovasc Diabetol. Published 20 May 2024. doi:10.
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