Trigeminal autonomic cephalgia due to pituitary adenomas: scoping review of the literature

Authors' conclusion

Patients with TACs secondary to pituitary adenomas are likely to be diagnosed with SUNCT, have associated secreting adenomas, and to underwent multiple trials of medications before reaching headache relief. In the included cases, TACs secondary to prolactinomas had improvement associated with medical management with dopamine agonist therapy. Surgical resection of pituitary adenomas in patients with medically refractory TACs and growth-secreting adenomas was also associated with significant improvement in headache severity. Further work is required to understand the exact pathophysiological mechanism for this rare disease in order to better treat this rare condition moving forward.