Proteomic Profiles Associated With Postsurgical Progression in Nonfunctioning Pituitary Adenomas
Authors' conclusion
This is the first exploratory study analyzing proteomic profiles as markers of postoperative tumor progression in NFPAs. The findings clearly showed different profiles between tumors with indolent postoperative behavior and those with postoperative tumor progression. Both enriched pathways involving DEPs and specific upregulated proteins have previously been associated with tumor aggressiveness. These results suggest the value of proteomic profiling for predicting tumor progression in patients with NFPAs.
Study context
- Population
- Patients with residual tumor following surgery for nonfunctioning pituitary adenomas (NFPAs) of gonadotroph lineage, tertiary university hospital
- Participants
- 46 patients
- Comparison
- Reintervention vs radiologically stable residual tumor
- Reinterventionn = 29
- Radiologically stablen = 17reference
- Outcome
- Differentially expressed proteins (DEPs) between groups
Methodological detailsexploratory, single tertiary university hospital
- Exploratory
- Single tertiary university hospital
Main finding
As reported in the abstract
Proteins identified
4074
Proteins differentially expressed between the 2 groups (fold change >80%, FDR-adjusted P ≤ .05)
550
Observational data: associations, not effects.
Original publication
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