Gestational diabetes & diabetes in pregnancy
Trajectory of serum bilirubin in offspring of women with gestational diabetes mellitus
Authors' conclusion
The findings suggest that future primary studies on hyperbilirubinemia risk in neonates of women with gestational diabetes should consider the trajectory of TSB beyond the first 48 h, adjusting for a more complete set of pre-pregnancy and gestational prognostic risk factors.
Study context
- Population
- Neonates of women with GDM delivered at Policlinic Abano, Abano Terme, Italy, October 2021 to May 2022
- Comparison
- Neonates of women with GDM vs controls
- GDMn = 69
- Outcome
- Total serum bilirubin (TSB) trajectory (mean percent variation of TSB) from birth
- Follow-up
- First 48 h after birth
Methodological details1:2 ratio
- 1:2 ratio
Main finding
As reported in the abstract
Mean percent variation of TSB · birth to 48 h
- GDM vs Controls: P = 0.01
Observational data: associations, not effects.
Further findings
TSB levels · 48 h of life · higher, although not significant, with GDM
P = 0.082
Cord TSB levels · birth · significantly lower with GDM
P = 0.010
Original publication
Trajectory of serum bilirubin in offspring of women with gestational diabetes mellitus. Diabetes Res Clin Pract. Published 26 March 2023. doi:10.
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