Trajectory of haemoglobin A1c and incidence of cardiovascular disease in patients with type 2 diabetes mellitus
Authors' conclusion
We found that T2DM patients with fluctuating HbA1c trajectories could have a higher CVD risk. Different trajectory-associated characteristics in age subgroups highlight the need for individualized management of T2DM patients.
Study context
- Population
- T2D patients with haemoglobin A1c (HbA1c) measurement after T2D diagnosis between August 2009 and September 2010; six subgroups by baseline HbA1c (<7%; 7%-7.9%; ≥8%) and age (<65; ≥65 years)median follow-up 11.7 years
- Participants
- 128,843 patients
- Exposure
- Latent classes of HbA1c trajectory and cardiovascular disease (CVD) incidence
- Outcome
- Association between HbA1c trajectory and concurrent CVD incidence
- Follow-up
- 12-year follow-up
Methodological detailsjoint latent class mixture models, 12-year follow-up
- Joint latent class mixture models
- 12-year follow-up
Main finding
As reported in the abstract
Latent classes identified in patients with baseline HbA1c ≥ 8% and age <65 years
10
Latent classes identified in each of the other five subgroups
7
Observational data: associations, not effects.
Further findings
Characteristics associated with a fluctuating HbA1c trajectory
- Male sex, higher baseline HbA1c and use of antidiabetic drugs more likely to have a fluctuating trajectory
- Age <65 years: younger age or smoking more likely to have a fluctuating trajectory
- Age ≥65 years: longer T2D duration more likely to have a fluctuating trajectory
Original publication
Trajectory of haemoglobin A1c and incidence of cardiovascular disease in patients with type 2 diabetes mellitus. Diabetes Obes Metab. Published 19 August 2024. doi:10.
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