Trajectories of triglyceride-glucose index changes and their association with all-cause and cardiovascular mortality: a competing risk analysis
Authors' conclusion
An increasing TyG index from baseline during follow-up was independently associated with higher risks of all-cause and CVD mortality. Serial monitoring of TyG index changes could enhance risk stratification and inform targeted interventions to reduce insulin resistance, and ultimately lower mortality risk.
Study context
- Population
- Adults aged ≥ 19 years, Korea National Health Insurance Service-National Sample Cohort
- Participants
- 233,546 adults
- Exposure
- Increasing vs stable vs decreasing triglyceride-glucose (TyG) index trajectories
- Outcome
- All-cause and CVD mortality
- Follow-up
- 8.13-year (2015-2021)
Methodological detailscompeting risk analysis
- Competing risk analysis
Main finding
As reported in the abstract
8.13-year follow-up
Each group vs stableEstimate (95% CI)
Increasing
aHR (all-cause mortality) 1.09(1.03–1.15)
Increasing
aHR (CVD mortality) 1.23(1.01–1.50)
- Mortality events
- 7918
- Cardiovascular disease (CVD) deaths
- 651
Observational data: associations, not effects.
Further findings
Subgroups: all-cause mortality with increasing TyG index
- Significant association in individuals aged < 50 years; men; and individuals with obesity, hypertension, diabetes, and/or dyslipidemia
Subgroups: CVD mortality with increasing TyG index
- Significant association in individuals aged 50-69 years, with obesity, with diabetes, or without dyslipidemia
Original publication
Trajectories of triglyceride-glucose index changes and their association with all-cause and cardiovascular mortality: a competing risk analysis. Cardiovasc Diabetol. Published 15 October 2024. doi:10.
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