Trabecular bone score and bone mineral density as indices of skeletal fragility in endogenous Cushing's syndrome
Authors' conclusion
TBS should be considered an important complementary tool in addition to BMD for the routine assessment of skeletal health in CS.
Study context
- Population
- Women with overt endogenous Cushing's syndrome (CS) and age and sex-matched healthy female controls
- Participants
- 40 vs 40
- Exposure
- Endogenous CS vs healthy controls
- CSn = 40
- Controlsn = 40reference
- Outcome
- BMD and bone microarchitecture by TBS
Methodological detailscase-control, age and sex-matched healthy controls
- Case-control
- Age and sex-matched healthy controls
Main finding
As reported in the abstract
- CS vs Controls: P < 0.001
- CS vs Controls: P = 0.055
Observational data: associations, not effects.
Further findings
- Normal bone mineral density (BMD) for age (Z-score ≥ −2.0) with low trabecular bone score (TBS) (L1-L4 TBS ≤ 1.34) in CS
- 32.5% · 13 of 40
Correlates of TBS in CS
- TBS correlated negatively with HbA1c
- P = 0.006
- TBS correlated positively with serum T4
- P = 0.027
Original publication
Trabecular bone score and bone mineral density as indices of skeletal fragility in endogenous Cushing's syndrome. Clin Endocrinol (Oxf). Published 4 July 2023. doi:10.
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