A preliminary model to tailor osilodrostat in patients with Adrenocorticotropic hormone (Adrenocorticotropin hormone (ACTH))-dependent Cushing's syndrome
Authors' conclusion
Our results report the first dose-response relationship between osilodrostat dose and cortisol levels, which should be helpful in identifying the optimal dosing regimen in patients with Cushing's syndrome and in individualizing treatment to approximate a nychthemeral rhythm.
Study context
- Population
- Patients with ACTH-dependent CS treated with osilodrostat
- Participants
- 18 patients
- Outcome
- Decrease in cortisol after initiation or dose change of osilodrostat
- Follow-up
- 48 hours
Methodological detailspreliminary kinetic-pharmacodynamic model, simulations, Simulations performed for different osilodrostat doses to evaluate variation in cortisol concentrations
- Preliminary kinetic-pharmacodynamic model
- Simulations
- Simulations performed for different osilodrostat doses to evaluate variation in cortisol concentrations
Main finding
As reported in the abstract
Dose-response relationship between osilodrostat dose and cortisol
- First dose-response relationship between osilodrostat dose and cortisol levels reported
Original publication
A preliminary model to tailor osilodrostat in patients with Adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome. Eur J Endocrinol. Published 16 September 2025. doi:10.
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