Tirzepatide 10 and 15 mg versus semaglutide 2.4 mg in people with obesity or overweight with type 2 diabetes: An indirect treatment comparison
Authors' conclusion
This analysis suggested greater reductions in bodyweight and HbA1c (%) levels associated with tirzepatide 10 and 15 mg than with semaglutide 2.4 mg in people with obesity or overweight and T2D.
Study context
- Population
- People with obesity or overweight and T2D
- Comparison
- Tirzepatide 10 and 15 mg vs semaglutide 2.4 mg
- Outcome
- Mean percent change in weight from baseline
- Follow-up
- Week 72 (tirzepatide) / week 68 (semaglutide)
Methodological detailsBucher method, efficacy estimand, sensitivity analyses: matching-adjusted indirect comparison, treatment regimen estimand, outcomes at 68 weeks
- Bucher method
- Efficacy estimand
- Sensitivity analyses: matching-adjusted indirect comparison, treatment regimen estimand, outcomes at 68 weeks
Main finding
As reported in the abstract
Mean difference
2.57 %
P < 0.01
Tirzepatide 10 mg
Mean difference
4.79 %
P < 0.01
Tirzepatide 15 mg
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Weight reduction ≥5%Tirzepatide 15 mgvs Semaglutide 2.4 mg | 1.76 (1.04–2.97) | P = 0.035 | |
| Weight reduction ≥5%Tirzepatide 10 mgvs Semaglutide 2.4 mg | 1.24 (0.75–2.04) | P = 0.407 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | Mean difference (%) | P value |
|---|---|---|
| Mean change in HbA1c (%)Tirzepatide 10 mg vs Semaglutide 2.4 mg · greater HbA1c reduction with tirzepatide | 0.47 | P < 0.001 |
| Mean change in HbA1c (%)Tirzepatide 15 mg vs Semaglutide 2.4 mg · greater HbA1c reduction with tirzepatide | 0.56 | P < 0.001 |
Sensitivity analyses
- Generally consistent with the primary analysis, exceptions including when power was reduced in the matching-adjusted indirect comparison analyses and in the categorical weight reduction outcome
Original publication
Tirzepatide 10 and 15 mg versus semaglutide 2.4 mg in people with obesity or overweight with type 2 diabetes: An indirect treatment comparison. Diabetes Obes Metab. Published 5 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →