Time‐restricted eating did not alter insulin sensitivity or β‐cell function in adults with obesity: A randomized pilot study
Authors' conclusion
In adults with overweight or obesity and without diabetes, TRE did not significantly alter insulin sensitivity, insulin secretion, or β-cell function over a 12-week intervention. Whether TRE is beneficial in adults with prediabetes or type 2 diabetes mellitus warrants further investigation.
Study context
- Population
- Adults with overweight or obesity, without diabetes, with a prolonged eating window (15.4 [SD 0.9] hours); 17 women/3 men, mean age 45.5 (SD 12.1) years, BMI 34.1 (SD 7.5) kg/m²17 women/3 men
- Participants
- 11 vs 9
- Comparison
- 12 weeks of time-restricted eating (TRE) vs unrestricted eating
- TREn = 11
- non-TREn = 9reference
- Primary endpoint
- OGTT-derived measures of insulin sensitivity, insulin secretion and β-cell function
- Follow-up
- End-intervention (12 weeks)
Methodological detailspilot
- Pilot
Primary result
As reported in the abstract
QUICKI, Stumvoll index, Avignon index, insulinogenic index, insulin AUC/glucose AUC, oral disposition index · end-intervention
- Did not differ between TRE and non-TRE at end-intervention
Original publication
Time‐restricted eating did not alter insulin sensitivity or β‐cell function in adults with obesity: A randomized pilot study. Obesity (Silver Spring). Published 14 December 2022. doi:10.
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